Sugar and Spike were two pre-speaking babies (Sugar Plumm and Cecil "Spike" Wilson) that could communicate via "baby talk" (a language only babies, not adults, could understand). Meyer did 98 issues in the original run, and some of the fun were reprinted in the Best Of DC in the 1980s.
Best Of DC #29 (October, 1981)
Best Of DC #41 (October, 1983)
This issue had reprints from Sugar and Spike #25, with the rest of the tales presented here from the European market, and unpublished in America until this issue came out.
Best Of DC #47 (April, 1984)
This issue had reprints from Sugar and Spike #1, #2, #9, #25, #27, #32, #52, #88, #89, #90, #91, #93 and #94, with no European only stories, and no other comedy additions, so it is all Sheldon Meyer goodness.
Best Of DC #58 (March, 1985)
This issue had reprints from Sugar and Spike #51, #68 and #95, which had a Christmas theme, as well as an all new story that didn't really connect to Sugar and Spike, with junior versions of the JLA members in a special story for the holidays.
Best Of DC #65 (October, 1985)
This issue had reprints from Sugar and Spike #37, #41, #46, #47, #48, #65, and #72, with all the excitement of Summer, as well as the first Bernie the Brain story.