Well, not really, but Casper did face a giant ape in two of his issues, Casper #129 (May, 1969) where he had to rescue Wendy the Good Witch from the super-sized simian....and later, in Casper #218 (October, 1981), where he put the fright into the giant ape.
Sadly, no records of the artists of these Harvey comic covers is available.
